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Drug: Aspirin

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Total 9959 results found since Jan 2013.

Platelet Inhibition With IV Glycoprotein IIb/IIIa Inhibitor to Prevent Thrombosis in Pediatric Patients Undergoing Aortopulmonary Shunting*
Objectives: Shunt thrombosis, a potential complication of aortopulmonary shunting, is associated with high mortality. Commonly used oral antiplatelet drugs such as aspirin demonstrate variable absorption and inconsistent antiplatelet effect in critically ill patients early after surgery. IV glycoprotein IIb/IIIa inhibitors are antiplatelet agents with rapid and reproducible effect that may be beneficial as a bridge to oral therapy. Design: Retrospective review of pediatric patients undergoing treatment with IV tirofiban. Discarded blood samples were used to determine pharmacokinetic parameters. Setting: Pediatric c...
Source: Pediatric Critical Care Medicine - June 1, 2020 Category: Pediatrics Tags: Online Cardiac Intensive Care Source Type: research

Exploratory Use of Glycoprotein IIb/IIIa Inhibition in Prevention of Blalock-Taussig Shunt Thrombosis*
OBJECTIVES: Morbidity and mortality related to modified Blalock-Taussig shunt (mBTTS) thrombosis remain a significant risk. Platelet inhibition following mBTTS may reduce this risk. However, oral antiplatelet agents have variable absorption following surgery. We determine risk factors for mBTTS thrombosis and hypothesize that IV glycoprotein IIb/IIIa inhibitor (tirofiban) as a bridge to oral aspirin reduces the rate of shunt thrombosis in the immediate postoperative period. End points within the 14-day follow-up period include mBTTS thrombosis, overall thrombosis, bleeding, length of stay, and mortality. DESIGN: ...
Source: Pediatric Critical Care Medicine - September 1, 2022 Category: Pediatrics Tags: Cardiovascular Critical Care Source Type: research

Prehospital Aspirin Use and Risk of ARDS in the Critically IllPrehospital Aspirin Use and Risk of ARDS in the Critically Ill
Learn more about the relationship between aspirin and ARDS. Critical Care Medicine
Source: Medscape Critical Care Headlines - May 8, 2015 Category: Intensive Care Tags: Critical Care Journal Article Source Type: news

Critical Care Compendium update
LITFL’s Critical Care Compendium is a comprehensive collection of pages concisely covering the core topics and controversies of critical care. Currently there are almost 1,500 entries with more in the works… Some pages are more developed than others, and all the pages are being constantly revised and improved. Links to new references and online resources are added daily, with an emphasis on those that are free and open access (FOAM!). These pages originated from the FCICM exam study notes created by Dr Jeremy Fernando in 2011, and have been updated, modified and added to since. As such will be particularly us...
Source: Life in the Fast Lane - November 17, 2013 Category: Emergency Medicine Doctors Authors: Chris Nickson Tags: Critical Care Compendium Education eLearning Emergency Medicine Featured CCC LITFL collection Source Type: blogs

Management of antiplatelet therapy in patients undergoing elective invasive procedures. Proposals from the French Working Group on perioperative haemostasis (GIHP) and the French Study Group on thrombosis and haemostasis (GFHT). In collaboration with the French Society for Anaesthesia and Intensive Care Medicine (SFAR)
Publication date: Available online 5 January 2018 Source:Anaesthesia Critical Care & Pain Medicine Author(s): Anne Godier, Pierre Fontana, Serge Motte, Annick Steib, Fanny Bonhomme, Sylvie Schlumberger, Thomas Lecompte, Nadia Rosencher, Sophie Susen, André Vincentelli, Yves Gruel, Pierre Albaladejo, Jean-Philippe Collet The French Working Group on Perioperative Haemostasis (GIHP) and the French Study Group on Haemostasis and Thrombosis (GFHT) in collaboration with the French Society for Anaesthesia and Intensive Care Medicine (SFAR) drafted up-to-date proposals for the management of antiplatelet therapy in patien...
Source: Anaesthesia, Critical Care and Pain Medicine - March 3, 2018 Category: Anesthesiology Source Type: research

Thrombo-prophylaxis in acutely ill medical and critically ill patients
Saurabh Saigal, Jai Prakash Sharma, Rajnish Joshi, Dinesh Kumar SinghIndian Journal of Critical Care Medicine 2014 18(6):382-391Thrombo-prophylaxis has been shown to reduce the incidence of pulmonary embolism (PE) and mortality in surgical patients. The purpose of this review is to find out the evidence-based clinical practice criteria of deep vein thrombosis (DVT) prophylaxis in acutely ill medical and critically ill patients. English-language randomized controlled trials, systematic reviews, and meta-analysis were included if they provided clinical outcomes and evaluated therapy with low-dose heparin or related agents co...
Source: Indian Journal of Critical Care Medicine - June 4, 2014 Category: Intensive Care Authors: Saurabh SaigalJai Prakash SharmaRajnish JoshiDinesh Kumar Singh Source Type: research

Aspirin resistance: Prevalence and clinical outcome in Egypt
Publication date: Available online 7 January 2015 Source:The Egyptian Journal of Critical Care Medicine Author(s): Ahmed Salah , Mohammed El-Desuky , Amal Rizk , Amr El-Hadidy Introduction The antiplatelet drug aspirin is considered as a cornerstone in medical treatment of patients with CV or cerebrovascular diseases. Despite its use, a significant number of patients had recurrent adverse ischemic events. Inter-individual variability of platelet aggregation in response to aspirin may be an explanation for some of these events. Multiple trials have linked aspirin resistance to these adverse events. Objectives The aim of ...
Source: The Egyptian Journal of Critical Care Medicine - January 8, 2015 Category: Intensive Care Source Type: research

Prophylaxis and incidence of symptomatic deep vein thrombosis in indian patients with sepsis: DETECT-deep vein thrombosis registry
Conclusions: Two-third patients received thromboprophylaxis. The substantial role of thromboprophylaxis in DVT prevention mandates monitoring and control of thromboprophylaxis through internal audits in hospitals.
Source: Indian Journal of Critical Care Medicine - November 13, 2017 Category: Intensive Care Authors: Nagarajan Ramakrishnan DETECT-DVT Investigators Source Type: research

Aspirin for Sepsis or Acute Respiratory Distress SyndromeAspirin for Sepsis or Acute Respiratory Distress Syndrome
This study examines the potential role aspirin could play in the treatment of sepsis and acute respiratory distress syndrome. Critical Care
Source: Medscape Critical Care Headlines - December 9, 2015 Category: Intensive Care Tags: Critical Care Journal Article Source Type: news

Increased Platelet Aggregation in Children and Adolescents with Sleep Disordered Breathing.
CONCLUSION: The finding of increased platelet aggregation is consistent with endothelial damage. This suggests that the profile of cardiovascular changes noted in adults with SDB may also occur in children with SDB. PMID: 32628860 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - July 5, 2020 Category: Respiratory Medicine Authors: Kontos A, Willoughby S, Lushington K, Martin J, Wabnitz D, Dorrian J, Kennedy D Tags: Am J Respir Crit Care Med Source Type: research

Management Of Antiplatelet Therapy In Patients Undergoing Elective Invasive Procedures Proposals From The French Working Group On Perioperative Hemostasis (Gihp) And The French Study Group On Thrombosis And Hemostasis (Gfht) In Collaboration With The French Society For Anesthesia And Intensive Care (Sfar)
Publication date: Available online 5 January 2018 Source:Anaesthesia Critical Care & Pain Medicine Author(s): Anne Godier, Pierre Fontana, Serge Motte, Annick Steib, Fanny Bonhomme, Sylvie Schlumberger, Thomas Lecompte, Nadia Rosencher, Sophie Susen, André Vincentelli, Yves Gruel, Pierre Albaladejo, Jean-Philippe Collet The French Working Group on Perioperative Hemostasis (GIHP) and the French Study Group on Hemostasis and Thrombosis (GFHT) in collaboration with the French Society for Anesthesia and Intensive Care (SFAR) drafted up-to-date proposals for the management of antiplatelet therapy in patients undergoin...
Source: Anaesthesia, Critical Care and Pain Medicine - January 6, 2018 Category: Anesthesiology Source Type: research

Postoperative care and analgesia in vascular surgery
Publication date: Available online 11 March 2016 Source:Anaesthesia & Intensive Care Medicine Author(s): Rachael L. Bird, Ian Nesbitt Patients undergoing major vascular surgery are high risk for myocardial infarction, renal failure, respiratory complications and death. Invasive procedures confer greater risk of complication, with patients undergoing open aortic surgery being at highest risk. Reduction of myocardial oxygen demand is key: stabilizing cardiovascular parameters, maintaining normothermia, adequate volume resuscitation and effective analgesia. Continuation of preoperative risk reduction strategies in...
Source: Anaesthesia and intensive care medicine - March 12, 2016 Category: Anesthesiology Source Type: research

Cytokines in Chronic Rhinosinusitis: Role in Eosinophilia and Aspirin Exacerbated Respiratory Disease.
CONCLUSIONS: CRSwNP was characterized by a predominant type-2 inflammatory environment while CRSsNP did not reflect a classic type-1 milieu, as has been previously suggested. AERD can be distinguished from CRSwNP by elevated ECP levels, but this enhanced eosinophilia is not associated with elevations in traditional type-2 inflammatory mediators associated with eosinophil proliferation and recruitment. However, other factors including GM-CSF, MCP-1, and t-PA may be important contributors to AERD pathogenesis. PMID: 26067893 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - June 11, 2015 Category: Respiratory Medicine Authors: Stevens WW, Ocampo CJ, Berdnikovs S, Sakashita M, Mahdavinia M, Suh L, Takabayashi T, Norton JE, Hulse KE, Conley DB, Chandra RK, Tan BK, Peters AT, Grammer Iii LC, Kato A, Harris KE, Carter RG, Fujieda S, Kern RC, Schleimer RP Tags: Am J Respir Crit Care Med Source Type: research